Research Article

P2Y12 Receptor on the Verge of a Neuroinflammatory Breakdown

Figure 5

P2Y12 receptor in human cortex. Sections from human healthy and SPMS frontal cortex were analyzed by double immunofluorescence and confocal microscopy for the immunoreactive markers c-ter (red, panels (a), (c); insets a1, a2, c1; yellow merged, inset c2), intra1 (red, panels (d), insets d1, d2, d3; yellow merged, panel f, insets f1, f2), MBP (green, panels (b), (c), (e), insets c1, e1; yellow merged, panel (f), inset f1), MHC II (green, inset d3), and integrin αII/β3 (green, insets b2, e2; yellow merged, insets c2, f2). The asterisks show decreased P2Y12 immunoreactivity in proximity to MS lesion.
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