Obesity, Inflammation, and Lung Injury (OILI): The Good

Figure 2

The major anti-inflammatory mechanism of adiponectin. Adiponectin polarizes macrophages from M1 to M2 and T helper cells from Th1 to Th2 and thus further increases immunity and has better anti-inflammatory effects. Furthermore, adiponectin activates AMPK and inhibits NF-κB signaling pathways and thus inhibits inflammation. Additionally, adiponectin inhibits oxidative stress and stimulates mitochondrial biogenesis. Under obese state, the production of adiponectin is lower which is correlated with worse proinflammation and possible lung injury.