Obesity, Inflammation, and Lung Injury (OILI): The Good
Table 1
Adipocytokines in obesity, inflammation, and lung injury: the good (trend).
Adipocytokine
Main functions*
Obesity
Inflammation
Lung injury
Agents available
Adipo-nectin
(1) Promotes weigh loss (2) Increases IS (3) Anti-inflammatory (4) Protects lung from injury
↓*
↓*
↓*
ADP355
Omentin
(1) Promotes weigh loss (2) Increases IS (3) Anti-inflammatory (4) Protects lung from injury
↓*
↓*
↓*
Recombinant
SFRP5
(1) Promotes weight loss (2) Increases IS (3) Anti-inflammatory (4) Protects lung from injury
↓*
↓*
↓*
Recombinant
Vaspin
(1) Decreases in obesity, T2DM, metabolic syndrome (2) Increases IS (3) Anti-inflammatory (4) No information in lung injury
↓*
↓*
?
Recombinant (OPPA00718)
ZAG
(1) Lipid mobilizer (2) Increases IS (3) Anti-inflammatory (4) No info in lung injury
↓*
↓*
?
Recombinant
IL-10
(1) Promotes weigh loss (2) Increases IS (3) Anti-inflammatory (4) Protects lung from injury
↓*
↓*
↓*
SCH52000 RN1003 IT9302 AM0010
IL-1RA
(1) Increases in obesity T2DM, metabolic syndrome, and lung injury (2) Encounters IL-1 and is anti-inflammatory
↑*
↑*
↑*
Recombinant (Anakinra)
TGF-β1
(1) Increases in obesity T2DM, metabolic syndrome, and lung injury (2) Anti-inflammatory
↑*
↑*
↑*
GC 1008 CAT-192 AP12009 LY2382770
GDF-15
(1) Increases in obesity, T2DM, metabolic syndrome, and lung injury; (2) Anti-inflammatory
↑*
↑*
↑*
Recombinant
*The majority of the evidence is supportive for this trend, but there were controversial reports. IS: insulin sensitivity. SFRP5: secreted frizzled-related proteins. IL: interleukin. ZAG: zinc-alpha2-glycoprotein. IL-1RA: interleukin 1 receptor antagonist. TGF: tumor growth factor. GDF: growth differentiation factor.
