Experimental Cannabinoid 2 Receptor-Mediated Immune Modulation in Sepsis

Figure 1

(a) Adherent leukocytes in collecting venules (V1; >50 μm vessel diameter). (b) Adherent leukocytes in postcapillary venules (V3; <50 μm vessel diameter). Control group (CON); endotoxemia group LPS (5 mg/kg); LPS + HU308 (2.5 mg/kg), a CB₂ receptor agonist; LPS + AM630 (2.5 mg/kg), a CB₂ receptor antagonist/inverse agonist; LPS + URB597 (0.6 mg/kg), a FAAH inhibitor; and LPS + JZL184 (16 mg/kg) a MAGL inhibitor. In every animal six V1 venules and six V3 venules were analyzed (𝑛=3–5 mice/group). Data presented as mean ± standard deviation. ^∗𝑃<0.05 versus control. ^#𝑃<0.05 versus LPS.

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