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Mediators of Inflammation
Volume 2015 (2015), Article ID 101987, 8 pages
http://dx.doi.org/10.1155/2015/101987
Research Article

The Hen or the Egg: Inflammatory Aspects of Murine MPN Models

1Division of Molecular Hematology, University Hospital Freiburg, Center for Clinical Research, Breisacher Straße 66, 79106 Freiburg, Germany
2Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Albertstraße 19A, 79104 Freiburg, Germany
3Faculty of Biology, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany

Received 30 June 2015; Accepted 16 August 2015

Academic Editor: Vladan P. Čokić

Copyright © 2015 Jonas S. Jutzi and Heike L. Pahl. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It has been known for some time that solid tumors, especially gastrointestinal tumors, can arise on the basis of chronic inflammation. However, the role of inflammation in the genesis of hematological malignancies has not been extensively studied. Recent evidence clearly shows that changes in the bone marrow niche can suffice to induce myeloid diseases. Nonetheless, while it has been demonstrated that myeloproliferative neoplasms (MPN) are associated with a proinflammatory state, it is not clear whether inflammatory processes contribute to the induction or maintenance of MPN. More provocatively stated: which comes first, the hen or the egg, inflammation or MPN? In other words, can chronic inflammation itself trigger an MPN? In this review, we will describe the evidence supporting a role for inflammation in initiating and promoting MPN development. Furthermore, we will compare and contrast the data obtained in gastrointestinal tumors with observations in MPN patients and models, pointing out the opportunities provided by novel murine MPN models to address fundamental questions regarding the role of inflammatory stimuli in the molecular pathogenesis of MPN.