MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives

Figure 4

Patients with MPNs have an increased risk of second cancer not only after the MPNs diagnosis but also in the pre-MPNs diagnosis phase, which may last several years in which the patients are at an increased risk of severe cardiovascular and thromboembolic events. According to this model, the initial stem cell insult has occurred 5–10–15 years before the MPNs diagnosis.