MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives

Figure 6

The MPNs care pathway and the effect of early intervention. It is suggested that ET, PV, and MF form a biological continuum and, thus, early intervention with combination therapies including JAK1/2 inhibitors, IFN, and/or statins is likely to result in the inhibition of disease evolution. ASCT: allogeneic stem cell transplantation; ET: essential thrombocythemia; HU: hydroxyurea; IFN: interferon; JAK: Janus kinase; MF: myelofibrosis; and PV: polycythemia vera (with permission: H. C. Hasselbalch [12]).