Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients

<div>Intestinal IL-17A mRNA expression increased with panobinostat treatment. Representative images for IL-17A RNAScope ISH from Patient <svg height="7.86364pt" id="M33" style="vertical-align:-0.5717597pt" version="1.1" viewbox="-0.0498162 -7.29188 9.74267 7.86364" width="9.74267pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M698 316L685 357H469L403 562H360L293 357H78L65 316L239 190L172 -15L207 -40L382 87L556 -40L590 -15L524 190L698 316Z"></path><glyph.data ascent="900" descent="-389" horiz-adv-x="739" vert-adv-y="739"></glyph.data></g></svg> are presented. Red arrowheads indicate a sampling of mRNA positive cell profiles in each image. Dashed lines demarcate lamina propria (LP) and epithelial (E) regions.</div>

Mediators of Inflammation

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Figure 4

Figure 4: Administration of Panobinostat Is Associated with Increased IL-17A mRNA in the Intestinal Epithelium of HIV-1 Patients 