Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans

Figure 2

LacCer-enriched microdomains. (a) Size of LacCer microdomains containing C16:0 and C24:0 fatty acid chain. (b) LacCer forms lipid microdomains on plasma membrane of human neutrophils and acts as a signal transduction platform. The C24 fatty acid chains of LacCer interdigitate into inner leaflet of plasma membranes and directly interact with Lyn and Gαi. These molecules associate with LacCer to mediate signaling from outside to inside, resulting in neutrophil chemotaxis, migration, and phagocytosis.

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