Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis

Table 3

Comparison of mRNA expression profiles of studied cytokines, chemokines, chemokine receptors, and T-bet between sarcoidosis (S) patients, subdivided according to the outcome after 2-year follow-up (Reg: regression; Prog: progression), and control subjects (C). All the data are presented as Mean Expression Level (95% confidence interval). Results are expressed relative to levels of a housekeeping gene PSMB2. : number of patients. Bold font indicates significant value.

	S	Reg S	Prog S	C
	( = 48)	( = 28)	( = 20)	( = 14)	(Kruskal-Wallis)	C versus S	Reg versus Prog
CCL2	0.058; (0.051–0.066)	0.051; (0.042–0.060)	0.069; (0.056–0.082)	0.069; (0.052–0.087)	0.950	0.602	0.875
CCL3	0.136; (0.118–0.154)	0.124; (0.100–0.147)	0.153; (0.126–0.181)	0.155; (0.120–0.190)	0.110	0.043	0.237
CCL4	2.022; (1.618–2.427)	1.676; (1.300–2.051)	2.508; (1.693–3.323)	2.023; (1.253–2.794)	0.157	0.034	0.746
CCL5	0.522; (0.462–0.582)	0.488; (0.409–0.567)	0.570; (0.473–0.667)	0.571; (0.432–0.711)	0.002	<0.001	0.834
CCL7	0.110; (0.071–0.150)	0.117; (0.050–0.184)	0.101; (0.077–0.124)	0.089; (0.042–0.137)	0.500	0.152	1.000
CCL8	0.364; (0.312–0.416)	0.319; (0.255–0.384)	0.421; (0.336–0.506)	0.362; (0.272–0.452)	0.147	0.031	1.000
CCL13	0.044; (0.034–0.054)	0.046; (0.029–0.062)	0.042; (0.031–0.052)	0.058; (0.020–0.096)	0.861	0.939	0.420
CCL19	0.054; (0.005–0.102)	0.077; (0.007–0.160)	0.021; (0.012–0.030)	0.057; (0.004–0.118)	0.477	0.216	0.403
CXCL2	0.012; (0.010–0.015)	0.012; (0.008–0.015)	0.013; (0.009–0.017)	0.014; (0.010–0.018)	0.429	0.414	0.161
CXCL3	0.304; (0.266–0.342)	0.294; (0.235–0.352)	0.319; (0.271–0.366)	0.196; (0.135–0.257)	0.069	0.608	0.011
CXCL9	0.061; (0.050–0.072)	0.056; (0.042–0.069)	0.068; (0.049–0.087)	0.074; (0.050–0.097)	0.005	<0.001	0.670
CXCL10	0.280; (0.219–0.340)	0.277; (0.199–0.355)	0.283; (0.179–0.386)	0.093; (0.061–0.125)	0.009	0.002	0.925
CXCL11	0.200; (0.170–0.231)	0.169; (0.138–0.200)	0.244; (0.187–0.300)	0.168; (0.126–0.210)	0.045	0.008	0.754
CXCL12	0.106; (0.091–0.121)	0.102; (0.084–0.120)	0.112; (0.085–0.139)	0.122; (0.091–0.153)	0.180	0.101	0.204
CXCL16	0.012; (0.010–0.014)	0.011; (0.008–0.014)	0.013; (0.009–0.016)	0.016; (0.007–0.024)	0.241	0.982	0.612
CCR1	0.009; (0.008–0.011)	0.010; (0.007–0.013)	0.013; (0.006–0.020)	0.014; (0.009–0.019)	0.289	0.277	0.112
CCR2-var.A	0.008; (0.006–0.010)	0.006; (0.005–0.007)	0.010; (0.005–0.015)	0.011; (0.007–0.015)	0.051	0.018	0.241
CCR2-var.B	0.026; (0.002–0.064)	0.039; (0.003–0.101)	0.010; (0.001–0.021)	0.005; (0.003–0.007)	0.779	0.444	0.587
CCR5	0.010; (0.008–0.013)	0.010; (0.008–0.012)	0.011; (0.006–0.017)	0.012; (0.009–0.016)	0.016	0.003	0.427
CXCR3	0.009; (0.006–0.011)	0.008; (0.006–0.010)	0.010; (0.005–0.014)	0.010; (0.005–0.014)	0.002	<0.001	0.691
CXCR4	0.038; (0.029–0.048)	0.059; (0.047–0.072)	0.065; (0.050–0.080)	0.062; (0.052–0.071)	0.295	0.152	0.271
CXCR6	0.808; (0.679–0.936)	0.815; (0.615–1.014)	0.798; (0.644–0.951)	0.901; (0.695–1.106)	<0.001	<0.001	0.616
CXCR7	0.061; (0.048–0.074)	0.060; (0.041–0.079)	0.065; (0.046–0.083)	0.089; (0.034–0.143)	0.667	0.392	0.417
IL2	0.103; (0.002–0.289)	0.013; (0.002–0.025)	0.009; (0.006–0.012)	0.018; (0.005–0.031)	<0.001	<0.001	0.730
IL2RA	0.038; (0.030–0.046)	0.041; (0.030–0.052)	0.035; (0.023–0.046)	0.058; (0.022–0.094)	0.210	0.051	0.730
IL2RB	0.038; (0.029–0.048)	0.059; (0.047–0.072)	0.065; (0.050–0.080)	0.062; (0.052–0.071)	0.131	0.049	0.272
IL15RA	0.808; (0.679–0.936)	0.815; (0.615–1.014)	0.798; (0.644–0.951)	0.901; (0.695–1.106)	0.182	0.048	0.530
IFNG	0.061; (0.048–0.074)	0.060; (0.041–0.079)	0.065; (0.046–0.083)	0.089; (0.034–0.143)	<0.001	<0.001	0.565
T-bet	0.103; (0.002–0.289)	0.013; (0.002–0.025)	0.009; (0.006–0.012)	0.018; (0.005–0.031)	0.031	0.006	0.573