Table 3: Comparison of mRNA expression profiles of studied cytokines, chemokines, chemokine receptors, and T-bet between sarcoidosis (S) patients, subdivided according to the outcome after 2-year follow-up (Reg: regression; Prog: progression), and control subjects (C). All the data are presented as Mean Expression Level (95% confidence interval). Results are expressed relative to levels of a housekeeping gene PSMB2. : number of patients. Bold font indicates significant value.

SReg SProg SC
( = 48)( = 28)( = 20)( = 14)(Kruskal-Wallis)C versus SReg versus Prog

CCL20.058
(0.051–0.066)
0.051
(0.042–0.060)
0.069
(0.056–0.082)
0.069
(0.052–0.087)
0.9500.6020.875

CCL30.136
(0.118–0.154)
0.124
(0.100–0.147)
0.153
(0.126–0.181)
0.155
(0.120–0.190)
0.1100.0430.237

CCL42.022
(1.618–2.427)
1.676
(1.300–2.051)
2.508
(1.693–3.323)
2.023
(1.253–2.794)
0.1570.0340.746

CCL50.522
(0.462–0.582)
0.488
(0.409–0.567)
0.570
(0.473–0.667)
0.571
(0.432–0.711)
0.002<0.0010.834

CCL70.110
(0.071–0.150)
0.117
(0.050–0.184)
0.101
(0.077–0.124)
0.089
(0.042–0.137)
0.5000.1521.000

CCL80.364
(0.312–0.416)
0.319
(0.255–0.384)
0.421
(0.336–0.506)
0.362
(0.272–0.452)
0.1470.0311.000

CCL130.044
(0.034–0.054)
0.046
(0.029–0.062)
0.042
(0.031–0.052)
0.058
(0.020–0.096)
0.8610.9390.420

CCL190.054
(0.005–0.102)
0.077
(0.007–0.160)
0.021
(0.012–0.030)
0.057
(0.004–0.118)
0.4770.2160.403

CXCL20.012
(0.010–0.015)
0.012
(0.008–0.015)
0.013
(0.009–0.017)
0.014
(0.010–0.018)
0.4290.4140.161

CXCL30.304
(0.266–0.342)
0.294
(0.235–0.352)
0.319
(0.271–0.366)
0.196
(0.135–0.257)
0.0690.6080.011

CXCL90.061
(0.050–0.072)
0.056
(0.042–0.069)
0.068
(0.049–0.087)
0.074
(0.050–0.097)
0.005<0.0010.670

CXCL100.280
(0.219–0.340)
0.277
(0.199–0.355)
0.283
(0.179–0.386)
0.093
(0.061–0.125)
0.0090.0020.925

CXCL110.200
(0.170–0.231)
0.169
(0.138–0.200)
0.244
(0.187–0.300)
0.168
(0.126–0.210)
0.0450.0080.754

CXCL120.106
(0.091–0.121)
0.102
(0.084–0.120)
0.112
(0.085–0.139)
0.122
(0.091–0.153)
0.1800.1010.204

CXCL160.012
(0.010–0.014)
0.011
(0.008–0.014)
0.013
(0.009–0.016)
0.016
(0.007–0.024)
0.2410.9820.612

CCR10.009
(0.008–0.011)
0.010
(0.007–0.013)
0.013
(0.006–0.020)
0.014
(0.009–0.019)
0.2890.2770.112

CCR2-var.A0.008
(0.006–0.010)
0.006
(0.005–0.007)
0.010
(0.005–0.015)
0.011
(0.007–0.015)
0.0510.0180.241

CCR2-var.B0.026
(0.002–0.064)
0.039
(0.003–0.101)
0.010
(0.001–0.021)
0.005
(0.003–0.007)
0.7790.4440.587

CCR50.010
(0.008–0.013)
0.010
(0.008–0.012)
0.011
(0.006–0.017)
0.012
(0.009–0.016)
0.0160.0030.427

CXCR30.009
(0.006–0.011)
0.008
(0.006–0.010)
0.010
(0.005–0.014)
0.010
(0.005–0.014)
0.002<0.0010.691

CXCR40.038
(0.029–0.048)
0.059
(0.047–0.072)
0.065
(0.050–0.080)
0.062
(0.052–0.071)
0.2950.1520.271

CXCR60.808
(0.679–0.936)
0.815
(0.615–1.014)
0.798
(0.644–0.951)
0.901
(0.695–1.106)
<0.001<0.0010.616

CXCR70.061
(0.048–0.074)
0.060
(0.041–0.079)
0.065
(0.046–0.083)
0.089
(0.034–0.143)
0.6670.3920.417

IL20.103
(0.002–0.289)
0.013
(0.002–0.025)
0.009
(0.006–0.012)
0.018
(0.005–0.031)
<0.001<0.0010.730

IL2RA0.038
(0.030–0.046)
0.041
(0.030–0.052)
0.035
(0.023–0.046)
0.058
(0.022–0.094)
0.2100.0510.730

IL2RB0.038
(0.029–0.048)
0.059
(0.047–0.072)
0.065
(0.050–0.080)
0.062
(0.052–0.071)
0.1310.0490.272

IL15RA0.808
(0.679–0.936)
0.815
(0.615–1.014)
0.798
(0.644–0.951)
0.901
(0.695–1.106)
0.1820.0480.530

IFNG0.061
(0.048–0.074)
0.060
(0.041–0.079)
0.065
(0.046–0.083)
0.089
(0.034–0.143)
<0.001<0.0010.565

T-bet0.103
(0.002–0.289)
0.013
(0.002–0.025)
0.009
(0.006–0.012)
0.018
(0.005–0.031)
0.0310.0060.573