Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats

Figure 2

Characterization of R32W and D145 effects on and currents. (a) Time course of normalized during repetitive depolarization from the holding potential to 0 mV before and after application of 10 pg R32W or 10 pg D145 (black arrow: time of application; white arrow: washout). (b) -curve of (black: control conditions; speckled line: after application of 10 pg R32W; dashed line: after application of 10 pg D145). Cells were depolarized to a variety of potentials (−60 to 60 mV) from a holding potential of –80 mV at increments of 10 mV to elicit . (c) Voltage-dependent reduction of after administration of 10 pg R32W or 10 pg D145. (d) Time course of normalized during repetitive depolarization from the holding potential to 0 mV before and after application of 100 pg R32W or 100 pg D145 (black arrow: time of application; white arrow: washout). (e) Time course of normalized and during repetitive depolarization from the holding potential to 0 mV before and after application of 10 pg R32W and 10 pg D145 (black arrow: time of application; white arrow: washout). (f) R32W and D145 dose-dependent increase in .

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