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Mediators of Inflammation
Volume 2015, Article ID 137357, 10 pages
http://dx.doi.org/10.1155/2015/137357
Review Article

Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease

1Oral & Dental Sciences Research Group, School of Medicine and Dentistry, University of Central Lancashire, Preston PR1 2HE, UK
2Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA

Received 13 January 2015; Accepted 1 April 2015

Academic Editor: Elisabetta Buommino

Copyright © 2015 Sim K. Singhrao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Periodontal disease (PD) and Alzheimer’s disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and alveolar bone resorption around the teeth. In health, junctional epithelium seals the gingiva to the tooth enamel, thus preventing bacteria from entering the gingivae. Chronic PD involves major pathogens (Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia) which have an immune armoury that can circumvent host’s immune surveillance to create and maintain an inflammatory mediator rich and toxic environment to grow and survive. The neurodegenerative condition, AD, is characterised by poor memory and specific hallmark proteins; periodontal pathogens are increasingly being linked with this dementing condition. It is therefore becoming important to understand associations of periodontitis with relevance to late-onset AD. The aim of this review is to discuss the relevance of finding the keystone periodontal pathogen P. gingivalis in AD brains and its plausible contribution to the aetiological hypothesis of this dementing condition.