3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway

Figure 2

Effects of AC-Rsv on LPS-induced mortality in mice. Mice from each experimental group were injected with 20 mg/kg of LPS with or without pretreatment of AC-Rsv (25, 50, and 100 mg/kg) for 7 days. Alive mice in each group were counted every 12 h. The accumulative mortalities of mice in middle-dose (50 mg/kg) and high-dose (100 mg/kg) groups were 55% and 65%, respectively, which were significantly lower than that of LPS group (80% mice dead) (). More importantly, 50 mg/kg of AC-Rsv exhibited the best protecting effect, , .