3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway

Figure 7

Effects of Rsv on the expression of MAPK/SIRT1 pathway in NR8383 cells stimulated by LPS. Relative expression levels of p-p38 MAPK, p-ERK, and p-NF-κB were normalized to the expression levels of their total forms; SIRT1 expression was expressed by comparing with that of β-actin. Stimulation of LPS significantly decreased the SIRT1 expression and increased the expression of p-p38 MAPK, p-ERK, and p-NF-κB in NR8383 cells compared with that of control, versus control, while Rsv treatment dramatically decreased p-p38 MAPK, p-ERK, and p-NF-κB expression and enhanced the expression of SIRT1 in NR8383 cells when challenged by LPS. versus .

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