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Mediators of Inflammation
Volume 2015, Article ID 143941, 5 pages
http://dx.doi.org/10.1155/2015/143941
Research Article

Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A)

1Laboratory of Pathology-Digestif-Oncology, Pasteur Institute of Morocco, 20360 Casablanca, Morocco
2Laboratory of Biology and Health, Molecular Modeling and Quality Control Team, Faculty of Sciences Ben M’sik, University Hassan II, 7955 Casablanca, Morocco
3Department of Radiotherapy Oncology, Ibn Rochd University Hospital, 20000 Casablanca, Morocco
4Laboratory of Molecular Genetics and Pathophysiology, Faculty of Sciences Ben M’sik, University Hassan II, 7955 Casablanca, Morocco

Received 25 December 2014; Revised 3 March 2015; Accepted 6 March 2015

Academic Editor: Madhav Bhatia

Copyright © 2015 A. Essadik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polymorphisms in tumor necrosis factor alpha (TNF-α) gene are emerging as key determinants of gastric diseases. The TNF-α−308 (G/A) and TNF-α−238 (G/A) single-nucleotide polymorphisms SNPs are the most extensively studied. However, all these studies are conducted in Caucasian and Asian populations. Thus, for the first time in Africa, we sought to investigate whether polymorphisms in TNF-α gene were associated with the development of gastric pathology in Morocco. Two SNPs located in the promoter region (positions −308 and −238) in TNF-α gene were genotyped in 244 individuals (170 patients and 74 healthy controls). Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression analysis. The TNF-α−238 (G/A) genotype was significantly associated with a high risk of gastritis and gastric cancer (GC) ( and , resp.). Furthermore, a new polymorphism located in the promoter region at position −193 in TNF-α gene was identified. The distribution of this SNP was markedly different in patients suffering from ulcers. The association between TNF-α−193 (G/A) genotype and high risk of ulcer was significant (). These results suggest that the TNF-α−193 (G/A) allele has a protective function against gastric cancer by developing ulcer.