Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α⁻¹⁹³ (G/A)

Table 2

Association of a new single-nucleotide polymorphisms TNF-⁻¹⁹³ (G/A) with gastric pathology.

	Genotypes	Genotyping frequency	MAF	OR	IC	value
Healthy patients	G/G	56 (75.68)	0.02	—	—	—
	A/G + A/A	16 (21.62)
Adenocarcinoma	G/G	77 (82.8)	0.12	0.64	(0.30–1.38)	0.25^NS
	A/G + A/A	16 (17.2)
Gastritis	G/G	44 (78.6)	0.18	0.84	(0.36–1.94)	0.69^NS
	A/G + A/A	12 (21.4)
Ulcer	G/G	11 (52.38)	0.40	2.82	1.03–7.74	0.03^S
	A/G + A/A	10 (47.62)

Data are expressed as %. TNF-: tumor necrosis factor alpha; A/G: adenine/guanidine; MAF: minor allele frequency; S: significant; NS: not significant ORs with 95% CI; and values were calculated for wild/wild genotype versus wild/mutant and mutant/mutant genotypes.