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Mediators of Inflammation
Volume 2015, Article ID 149381, 12 pages
http://dx.doi.org/10.1155/2015/149381
Research Article

Protection from Endotoxic Uveitis by Intravitreal Resolvin D1: Involvement of Lymphocytes, miRNAs, Ubiquitin-Proteasome, and M1/M2 Macrophages

1Multisciplinary Department of Medical-Surgical and Dental Specialities, Second University of Naples, Via Pansini 5, 80131 Naples, Italy
2Section of Pharmacology “L. Donatelli”, Department of Experimental Medicine, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
3DiSTABiF, Second University of Naples, Via Vivaldi 43, 81100 Caserta, Italy
4Department of Clinical, Public and Preventive Medicine, Second University of Naples, Via Armanni 5, 80138 Naples, Italy

Received 24 June 2014; Revised 13 November 2014; Accepted 8 December 2014

Academic Editor: Marc Pouliot

Copyright © 2015 S. Rossi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Deschenes, P. I. Murray, N. A. Rao, and International Uveitis Study Group, “International Uveitis Study Group: clinical classification of uveitis,” Ocular Immunology & Inflammation, vol. 16, no. 1, pp. 1–2, 2008. View at Publisher · View at Google Scholar
  2. A. D. Dick, “The treatment of chronic uveitic macular oedema.,” British Journal of Ophthalmology, vol. 78, no. 1, pp. 1–2, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. W. A. Franks, G. A. Limb, M. R. Stanford et al., “Cytokines in human intraocular inflammation,” Current Eye Research, vol. 11, pp. 187–191, 1992. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Rossi, D. F. Clara, F. Franca, S. Francesca, and D. Michele, “Resolvin D1 reduces the immunoinflammatory response of the rat eye following uveitis,” Mediators of Inflammation, vol. 2012, Article ID 318621, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. E. C. Ebert, “Infliximab and the TNF-alpha system,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 296, no. 3, pp. G612–G620, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. H. Hosseini and E. Salehifar, “Social phobia following maprotiline: the first case report,” Cases Journal, vol. 2, no. 12, article 9340, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Demir, A. Gödekmerdan, M. Balbaba, P. Türkçüoglu, F. Ilhan, and N. Demir, “The effect of infliximab, cyclosporine A and recombinant IL-10 on vitreous cytokine levels in experimental autoimmune uveitis,” Indian Journal of Ophthalmology, vol. 54, no. 4, pp. 241–245, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. T. R. Thrimawithana, S. Young, C. R. Bunt, C. Green, and R. G. Alany, “Drug delivery to the posterior segment of the eye,” Drug Discovery Today, vol. 16, no. 5-6, pp. 270–277, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. Y.-P. Sun, S. F. Oh, J. Uddin et al., “Resolvin D1 and its aspirin-triggered 17R epimer: stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation,” The Journal of Biological Chemistry, vol. 282, no. 13, pp. 9323–9334, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Chen, Z. Xie, X. Wu et al., “Intravitreal injection of soluble erythropoietin receptor exacerbates photoreceptor cell apoptosis in a rat model of retinal detachment,” Current Eye Research, vol. 37, no. 12, pp. 1156–1164, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. L. L. Tian, B. Ren, X. W. Gao et al., “Inhibition of retinopathy of prematurity in rat by intravitreal injection of sorafenib,” International Journal of Ophthalmology, vol. 7, no. 2, pp. 198–204, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. M. R. Romano, F. Biagioni, G. Besozzi et al., “Effects of bevacizumab on neuronal viability of retinal ganglion cells in rats,” Brain Research, vol. 1478, pp. 55–63, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. A. L. Alessandri, L. P. Sousa, C. D. Lucas, A. G. Rossi, V. Pinho, and M. M. Teixeira, “Resolution of inflammation: mechanisms and opportunity for drug development,” Pharmacology and Therapeutics, vol. 139, no. 2, pp. 189–212, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Cuello, D. Wakefield, and N. Di Girolamo, “Neutrophil accumulation correlates with type IV collagenase/gelatinase activity in endotoxin induced uveitis,” British Journal of Ophthalmology, vol. 86, no. 3, pp. 290–295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. A. M. Vicente, M. I. Guillén, and M. J. Alcaraz, “Participation of heme oxygenase-1 in a model of acute inflammation,” Experimental Biology and Medicine, vol. 228, no. 5, pp. 514–516, 2003. View at Google Scholar · View at Scopus
  16. S. Rivière, L. Challet, D. Fluegge, M. Spehr, and I. Rodriguez, “Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors,” Nature, vol. 459, no. 7246, pp. 574–577, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Odusanwo, S. Chinthamani, A. McCall, M. E. Duffey, and O. J. Baker, “Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation,” American Journal of Physiology—Cell Physiology, vol. 302, no. 9, pp. C1331–C1345, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. B. D. Levy, “Resolvins and protectins: natural pharmacophores for resolution biology,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 82, no. 4–6, pp. 327–332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. C. J. Loscher, K. Hokamp, J. H. Wilson et al., “A common microRNA signature in mouse models of retinal degeneration,” Experimental Eye Research, vol. 87, no. 6, pp. 529–534, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. C. J. Loscher, K. Hokamp, P. F. Kenna et al., “Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa,” Genome Biology, vol. 8, no. 11, article R248, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. W. Ishida, K. Fukuda, T. Higuchi, M. Kajisako, S. Sakamoto, and A. Fukushima, “Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis,” Investigative Ophthalmology and Visual Science, vol. 52, no. 1, pp. 611–617, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Xu, “microRNA expression in the eyes and their significance in relation to functions,” Progress in Retinal and Eye Research, vol. 28, no. 2, pp. 87–116, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. K.-W. Lee, Y. Teng, H.-K. Wong et al., “MicroRNA-145 regulates human corneal epithelial differentiation,” PLoS ONE, vol. 6, Article ID e21249, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Conkrite, M. Sundby, S. Mukai et al., “Mir-17~92 cooperates with RB pathway mutations to promote retinoblastoma,” Genes and Development, vol. 25, no. 16, pp. 1734–1745, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. A. di Francesco, C. de Pittà, F. Moret, V. Barbieri, L. Celotti, and M. Mognato, “The DNA-Damage Response to γ-radiation is affected by miR-27a in A549 cells,” International Journal of Molecular Sciences, vol. 14, no. 9, pp. 17881–17896, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Hoesel and J. A. Schmid, “The complexity of NF-κB signaling in inflammation and cancer,” Molecular Cancer, vol. 12, article 86, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Bae, E.-J. Lee, J. H. Lee et al., “Oridonin protects HaCaT keratinocytes against hydrogen peroxide-induced oxidative stress by altering microRNA expression,” International Journal of Molecular Medicine, vol. 33, no. 1, pp. 185–193, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. S. D. Varma and S. Kovtun, “Protective effect of caffeine against high sugar-induced transcription of microRNA and consequent gene silencing: a study using lenses of galactosemic mice,” Molecular Vision, vol. 19, pp. 493–500, 2013. View at Google Scholar · View at Scopus
  29. X. Ma, L. E. B. Buscaglia, J. R. Barker, and Y. Li, “MicroRNAs in NF-κB signaling,” Journal of Molecular Cell Biology, vol. 3, no. 3, pp. 159–166, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. C. E. Monk, G. Hutvagner, and J. S. C. Arthur, “Regulation of miRNA transcription in macrophages in response to Candida albicans,” PLoS ONE, vol. 5, no. 10, Article ID e13669, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Sallam, S. R. J. Taylor, and S. Lightman, “Review and update of intraocular therapy in noninfectious uveitis,” Current Opinion in Ophthalmology, vol. 22, no. 6, pp. 517–522, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. S. R. J. Taylor, H. Isa, L. Joshi, and S. Lightman, “New developments in corticosteroid therapy for uveitis,” Ophthalmologica, vol. 224, no. 1, pp. 46–53, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Reis, F. Hassan, X. Q. Guan et al., “The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages,” Cell Biochemistry and Biophysics, vol. 60, no. 1-2, pp. 119–126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Bunda, K. Kommaraju, P. Heir, and M. Ohh, “SOCS-1 mediates ubiquitylation and degradation of GM-CSF receptor,” PLoS ONE, vol. 8, no. 9, Article ID e76370, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Kimura and T. Nishida, “Role of the ubiquitin-proteasome pathway in downregulation of the gap-junction protein connexin43 by TNF-α in human corneal fibroblasts,” Investigative Ophthalmology and Visual Science, vol. 51, no. 4, pp. 1943–1947, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. X. Yu and D. C. Kem, “Proteasome inhibition during myocardial infarction,” Cardiovascular Research, vol. 85, no. 2, pp. 312–320, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. Z. Zemeckienė, A. Vitkauskienė, T. Sjakste, B. Sitkauskienė, and R. Sakalauskas, “Proteasomes and proteasomal gene polymorphism in association with inflammation and various diseases,” Medicina, vol. 49, no. 5, pp. 207–213, 2013. View at Google Scholar · View at Scopus