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Mediators of Inflammation
Volume 2015, Article ID 176726, 7 pages
http://dx.doi.org/10.1155/2015/176726
Research Article

Innate Immunity Components and Cytokines in Gastric Mucosa in Children with Helicobacter pylori Infection

1Chair of Immunology, Collegium Medicum Nicolaus Copernicus University, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland
2Department of Clinical Microbiology and Immunology, The Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland
3Department of Pediatrics, Allergology and Gastroenterology, Collegium Medicum Nicolaus Copernicus University, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland
4Department of Pediatric Endoscopy and Gastrointestinal Function Testing, Collegium Medicum Nicolaus Copernicus University, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland
5Department of Clinical Pathomorphology, Collegium Medicum Nicolaus Copernicus University, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland
6Department of Oncologic Pathology, The Greater Poland Cancer Centre, Garbary 15, 61-866 Poznan, Poland
7Institute of Nursery and Public Health, Rzeszow University, Al. Rejtana 16A, 35-310 Rzeszow, Poland

Received 13 June 2014; Accepted 18 August 2014

Academic Editor: Ishak O. Tekin

Copyright © 2015 Jacek Michalkiewicz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Pimentel-Nunes, L. Afonso, P. Lopes et al., “Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia,” Pathology and Oncology Research, vol. 17, no. 3, pp. 677–683, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Rad, L. Brenner, A. Krug et al., “Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori,” Gastroenterology, vol. 133, no. 1, pp. 150.e3–163.e3, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Müller, M. Oertli, and I. C. Arnold, “H. Pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection,” Cell Communication and Signaling, vol. 9, article 25, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Schmaußer, M. Andrulis, S. Endrich et al., “Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection,” Clinical and Experimental Immunology, vol. 136, no. 3, pp. 521–526, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Obonyo, M. Sabet, S. P. Cole et al., “Deficiencies of myeloid differentiation factor 88, toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori,” Infection and Immunity, vol. 75, no. 5, pp. 2408–2414, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Mandell, A. P. Moran, A. Cocchiarella et al., “Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4,” Infection and Immunity, vol. 72, no. 11, pp. 6446–6454, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Schmaußer, S. Endrich, D. Beier et al., “Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium: implication for a role of TREM-1 in Helicobacter pylori infection,” Clinical and Experimental Immunology, vol. 152, no. 1, pp. 88–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. M. G. Netea, T. Azam, G. Ferwerda, S. E. Girardin, S.-H. Kim, and C. A. Dinarello, “Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors,” Journal of Leukocyte Biology, vol. 80, no. 6, pp. 1454–1461, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. G.-Y. Sun, C.-X. Guan, Y. Zhou et al., “Vasoactive intestinal peptide re-balances TREM-1/TREM-2 ratio in acute lung injury,” Regulatory Peptides, vol. 167, no. 1, pp. 56–64, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Radhakrishnan, L. N. Arneson, J. L. Upshaw et al., “TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells,” The Journal of Immunology, vol. 181, no. 11, pp. 7863–7872, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Ito and J. A. Hamerman, “TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells,” European Journal of Immunology, vol. 42, no. 1, pp. 176–185, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. M. M. van den Heuvel, C. P. Tensen, J. H. van As et al., “Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation,” Journal of Leukocyte Biology, vol. 66, no. 5, pp. 858–866, 1999. View at Google Scholar · View at Scopus
  13. M. Ritter, C. Buechler, T. Langmann, E. Orso, J. Klucken, and G. Schmitz, “The scavenger receptor CD163: regulation, promoter structure and genomic organization,” Pathobiology, vol. 67, no. 5-6, pp. 257–261, 2000. View at Google Scholar · View at Scopus
  14. Y. Komohara, J. Hirahara, T. Horikawa et al., “AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype,” Journal of Histochemistry and Cytochemistry, vol. 54, no. 7, pp. 763–771, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Quiding-Jarbrink, S. Raghavan, and M. Sundquist, “Enhanced M1 macrophage polarization in human Helicobacter pylori-associated atrophic gastritis and in vaccinated mice,” PLoS ONE, vol. 5, no. 11, Article ID e15018, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. B. O. Fabriek, R. V. Bruggen, D. M. Deng et al., “The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria,” Blood, vol. 113, no. 4, pp. 887–892, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. C. M. Bliss Jr., D. T. Golenbock, S. Keates, J. K. Linevsky, and C. P. Kelly, “Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes,” Infection and Immunity, vol. 66, no. 11, pp. 5357–5363, 1998. View at Google Scholar · View at Scopus
  18. M. D. Cunningham, C. Seachord, K. Ratcliffe, B. Bainbridge, A. Aruffo, and R. P. Darveau, “Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14,” Infection and Immunity, vol. 64, no. 9, pp. 3601–3608, 1996. View at Google Scholar · View at Scopus
  19. A. Gzyl, D. Dzierzanowska, E. Rozynek, D. Celińska-Cedro, W. Dura, and D. E. Berg, “PCR-based diagnosis of Helicobacter pylori infection in Polish children and adults,” Journal of Medical Microbiology, vol. 48, no. 4, pp. 349–356, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Galal, W. El-Beialy, Y. Deyama et al., “Up-regulation of the G3PDH “housekeeping” gene by estrogen,” Molecular Medicine Reports, vol. 3, no. 1, pp. 111–113, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Ornatowska, A. C. Azim, X. Wang et al., “Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages,” American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 293, no. 6, pp. L1377–L1384, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. A. Schaer, F. Vallelian, A. Imhof, G. Schoedon, and D. J. Schaer, “CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system,” Journal of Leukocyte Biology, vol. 82, no. 1, pp. 106–110, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Gangloff and N. J. Gay, “MD-2: the Toll “gatekeeper” in endotoxin signalling,” Trends in Biochemical Sciences, vol. 29, no. 6, pp. 294–300, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Remmele and H. E. Stegner, “Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue,” Pathologe, vol. 8, no. 3, pp. 138–140, 1987. View at Google Scholar · View at Scopus
  25. F. Luzza, T. Parrello, L. Sebkova et al., “Expression of proinflammatory and Th1 but not Th2 cytokines is enhanced in gastric mucosa of Helicobacter pylori infected children,” Digestive and Liver Disease, vol. 33, no. 1, pp. 14–20, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Lagunes-Servin, J. Torres, C. Maldonado-Bernal et al., “Toll-like receptors and cytokines are upregulated during Helicobacter pylori infection in children,” Helicobacter, vol. 18, no. 6, pp. 423–432, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Rad, W. Ballhorn, P. Voland et al., “Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori,” Gastroenterology, vol. 136, no. 7, pp. 2247–2257, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Sato, O. Takeuchi, T. Fujita, H. Tomizawa, K. Takeda, and S. Akira, “A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways,” International Immunology, vol. 14, no. 7, pp. 783–791, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. S. S. Zaric, W. A. Coulter, C. E. Shelburne et al., “Altered toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon β production,” The Journal of Biological Chemistry, vol. 286, no. 34, pp. 29492–29500, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Amedei, A. Cappon, G. Codolo et al., “The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses,” Journal of Clinical Investigation, vol. 116, no. 4, pp. 1092–1101, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Erridge, A. Pridmore, A. Eley, J. Stewart, and I. R. Poxton, “Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via Toll-like receptor 2,” Journal of Medical Microbiology, vol. 53, no. 8, pp. 735–740, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. S.-I. Yokota, T. Ohnishi, M. Muroi, K.-I. Tanamoto, N. Fujii, and K.-I. Amano, “Highly-purified Helicobacter pylori LPS preparations induce weak inflammatory reactions and utilize Toll-like receptor 2 complex but not Toll-like receptor 4 complex,” FEMS Immunology and Medical Microbiology, vol. 51, no. 1, pp. 140–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Dzierzanowska-Fangrat, J. Michalkiewicz, J. Cielecka-Kuszyk et al., “Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1β mRNA expression,” European Journal of Gastroenterology and Hepatology, vol. 20, no. 4, pp. 314–319, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Fehlings, L. Drobbe, V. Moos et al., “Comparative analysis of the interaction of Helicobacter pylori with human dendritic cells, macrophages, and monocytes,” Infection and Immunity, vol. 80, no. 8, pp. 2724–2734, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. C. H. Yun, A. Lundgren, J. Azem et al., “Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production,” Infection and Immunity, vol. 73, no. 3, pp. 1482–1490, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Shimazu, S. Akashi, H. Ogata et al., “MD-2, a molecule that confers lipopolysaccharide responsiveness on toll- like receptor 4,” Journal of Experimental Medicine, vol. 189, no. 11, pp. 1777–1782, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Asahi, Y. F. Hai, Y. Hayashi et al., “Helicobacter pylori infection affects toll-like receptor 4 expression in human gastric mucosa,” Hepato-Gastroenterology, vol. 54, no. 79, pp. 1941–1944, 2007. View at Google Scholar · View at Scopus
  38. P. Pimentel-Nunes, A. L. Teixeira, C. Pereira et al., “Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans,” Digestive and Liver Disease, vol. 45, no. 1, pp. 63–69, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Helmin-Basa, M. Czerwionka-Szaflarska, G. Bala et al., “Expression of adhesion and activation molecules on circulating monocytes in children with Helicobacter pylori infection,” Helicobacter, vol. 17, no. 3, pp. 181–186, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. C. Buechler, M. Ritter, E. Orsó, T. Langmann, J. Klucken, and G. Schmitz, “Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli,” Journal of Leukocyte Biology, vol. 67, no. 1, pp. 97–103, 2000. View at Google Scholar · View at Scopus
  41. D. A. Joyce, D. P. Gibbons, P. Green, J. H. Steer, M. Feldmann, and F. M. Brennan, “Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes,” European Journal of Immunology, vol. 24, no. 11, pp. 2699–2705, 1994. View at Publisher · View at Google Scholar · View at Scopus
  42. R. P. Donnelly, H. Dickensheets, and D. S. Finbloom, “The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes,” Journal of Interferon and Cytokine Research, vol. 19, no. 6, pp. 563–573, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. F. Freire de Melo, A. M. C. Rocha, G. A. Rocha et al., “A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children,” Microbes and Infection, vol. 14, no. 4, pp. 341–347, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. J. H. Gil, J. W. Seo, M.-S. Cho, J.-H. Ahn, and H. Y. Sung, “Role of Treg and TH17 cells of the gastric mucosa in children with Helicobacter pylori gastritis,” Journal of Pediatric Gastroenterology and Nutrition, vol. 58, no. 2, pp. 245–251, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. K. L. Laurie, I. R. van Driel, and P. A. Gleeson, “The role of CD4+CD25+ immunoregulatory T cells in the induction of autoimmune gastritis,” Immunology and Cell Biology, vol. 80, no. 6, pp. 567–573, 2002. View at Publisher · View at Google Scholar · View at Scopus