Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice

Figure 10

Periodic acid Schiff- (PAS-) stained lung tissue. Airways of mice taken from (a) naïve mice, (b) OVA-challenged mice, (c) dexamethasone-treated mice, (d) 100 mg/kg DMPF-1-treated mice, (e) 20 mg/kg DMPF-1-treated mice, (f) 2 mg/kg DMPF-1-treated mice, and (g) 0.2 mg/kg DMPF-1-treated mice. The goblet cells are indicated by black arrows. These photos were taken under 40x objective (400x magnification) using light microscope (Bar = 50 μm). This experiment used 10 mice per group (). (h) For quantitative analysis of goblet cell hyperplasia, the number of goblet cells in each airway was counted and the sum of the goblet cells was divided by the total number of airways in each slide. The values are expressed as mean ± SEM (). , significantly different from the OVA-challenged group.

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