Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-<i>κ</i>B Nuclear Translocation and Suppression of Experimental Asthma in Mice

<div>Schematic diagram of the<i> in vivo</i> experimental protocol. Mice were sensitized intraperitoneally with OVA (500 <i>μ</i>g/mL) and 10% (w/v) alum on days 0, 7, and 14. On days 21, 22, and 23, sensitized mice were pretreated with DMPF-1 intraperitoneally one hour prior to challenge with aerosolized OVA (1%) (w/v). BHR was measured 24 hrs after the last OVA challenge (day 24). The mice were sacrificed on day 27 and BALF, serum, and lung tissues were collected for total and differential cell counts, histopathological evaluation, immunoassay, and RT-PCR.</div>

Mediators of Inflammation

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Figure 2: Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-<i>κ</i>B Nuclear Translocation and Suppression of Experimental Asthma in Mice 

Figure 2 | Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice 