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Mediators of Inflammation
Volume 2015, Article ID 182872, 9 pages
http://dx.doi.org/10.1155/2015/182872
Review Article

Nonmuscle Tissues Contribution to Cancer Cachexia

1Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
2Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
3BSA Nutrition Centre, 08195 Barcelona, Spain

Received 15 December 2014; Accepted 26 March 2015

Academic Editor: Yona Keisari

Copyright © 2015 Josep M. Argilés et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cachexia is a syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting, and inflammation, being often associated with anorexia. In spite of the fact that muscle tissue represents more than 40% of body weight and seems to be the main tissue involved in the wasting that occurs during cachexia, recent developments suggest that tissues/organs such as adipose (both brown and white), brain, liver, gut, and heart are directly involved in the cachectic process and may be responsible for muscle wasting. This suggests that cachexia is indeed a multiorgan syndrome. Bearing all this in mind, the aim of the present review is to examine the impact of nonmuscle tissues in cancer cachexia.