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Mediators of Inflammation
Volume 2015, Article ID 196702, 10 pages
http://dx.doi.org/10.1155/2015/196702
Research Article

ADAMTS-7 Exhibits Elevated Expression in Cartilage of Osteonecrosis of Femoral Head and Has a Positive Correlation with TNF-α and NF-κB P65

1Department of Orthopaedic Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012, China
2Medical College of Shandong University, Jinan, Shandong 250012, China

Received 11 November 2014; Revised 17 December 2014; Accepted 17 December 2014

Academic Editor: Luca Cantarini

Copyright © 2015 Jing-kun Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

ADAMTS-7 has been reported to exaggerate cartilage degeneration and to be associated with TNF-α and NF-κB signaling pathway. In this study we compared the expression of ADAMTS-7, TNF-α, and Phospho-NF-κB in patients with femoral neck fracture (FNF) and osteonecrosis of femoral head (ONFH) at different stages. We found that expression of ADAMTS-7, TNF-α, and Phospho-NF-κB was significantly upregulated in ONFH patients’ articular cartilage and related to the pathogenesis of ONFH. Thus we conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-α and Phospho-NF-κB P65 in cartilage, which may imply its association with cartilage destruction of ONFH.