Sepsis and ARDS: The Dark Side of Histones

Table 1

Sepsis-associated organ dysfunction induced by extracellular histones.

Organ dysfunction	Mechanism	Reference
Lung injury	Cytotoxicity, NLRP3 inflammasome	[42, 59, 74]
Cardiac injury	Cytotoxicity	[43, 60, 74]
Liver injury	Proinflammation	[74, 75]
Kidney injury	Proinflammation, cytotoxicity	[30, 74]
Spleen injury	Cytotoxicity	[74, 76]
Coagulation	Platelets activation, thrombosis	[39, 63, 67]