Mediators of Inflammation

Research Article

Increased Migratory and Activation Cell Markers of Peripheral Blood Lymphocytes in an Experimental Model of Nephrotic Syndrome

Table 1

Urinary protein excretion, blood cells, and markers of cell surface and of redox status in the kidney of rats with doxorubicin-induced nephropathy and controls.
 Control Group Doxorubicin goup
T-07T-14T-21T-28
 Mean (SE)Mean (SE)Mean (SE)Mean (SE)Mean (SE)
Albuminuria (mg/L)62.92 (18.09)122.66 (23.17)102.43 (16.57)87.05 (3.43)79.06 (7.90)
Urine albumin/creatinine ratio (mg/g)0.39 (0.07)0.92 (0.18)1.05 (0.35)1.09 (0.41)0.98 (0.11)
WBC × 10006.81 (0.58)3.14 (0.14)8.37 (0.82)10.87 (1.09)7.5 (0.96)
Monocytes (%)6.07 (0.52)4.19 (0.70)7.19 (2.40)7.13 (0.76)3.20 (0.78)
Neutrophil (%)14.45 (1.16)10.00 (1.29)34.77 (3.16)20.87 (3.94)33.70 (4.25)
Lymphocyte (%)79.17 (2.45)85.49 (1.41)57.24 (4.59)71.55 (2.23)62.50 (4.40)
Eosinophil (%)0.18 (0.06)0.20 (0.13)0.10 (0.10)0.26 (0.21)0.30 (0.21)
Basophil (%)0.13 (0.11)0.11 (0.11)0.70 (0.30)0.18 (0.13)0.30 (0.21)
Monocytes × 10000.414 (0.185)0.132 (0.053)0.602 (0.783)0.775 (0.257)0.240 (0.174)
Neutrophil × 10000.984 (0.465)0.314 (0.084)2.910 (1.375)2.269 (1.074)2.528 (1.414)
Lymphocyte × 10005.391 (1.415)2.684 (0.304)4.791 (1.053)7.778 (1.294)4.688 (0.618)
Eosinophil × 10000.012 (0.024)0.000 (0.00)0.008 (0.019)0.029 (0.050)0.023 (0.048)
Basophil × 10000.009 (0.018)0.003 (0.01)0.059 (0.093)0.019 (0.046)0.023 (0.056)
T cell CD3+CD4+ (%)45.94 (1.70)79.92 (1.92)57.53 (2.03)47.93 (4.30)47.86 (3.52)
T cell CD3+CD8+ (%)13.41 (0.55)16.19 (1.00)12.09 (1.74)12.70 (0.92)13.40 (0.88)
T cell CD4+CD18+ (MFI)10.72 (0.52)11.54 (1.18)12.43 (0.57)12.65 (1.60)12.02 (1.07)
MDA (mmol/mg protein)2.18 (0.11)3.32 (0.51)2.62 (0.40)2.09 (0.52)1.80 (0.22)
Catalase (ΔE/min/mg protein).4.61 (0.37)5.83 (1.63)4.97 (0.89)4.94 (0.91)4.21 (0.47)
SOD (U/mg protein)0.39 (0.02)0.36 (0.04)0.32 (0.02)0.42 (0.02)0.38 (0.02)
MDA: malondialdehyde; SOD: superoxide dismutase.
compared to control group.