Altered Innate Immune Responses in Neutrophils from Patients with Well- and Suboptimally Controlled Asthma

Figure 3

MMP-9 release from neutrophils stimulated with bacterial and viral mimetics and RV16. MMP-9 release from healthy controls (blue circles, ), well-controlled asthmatic (green squares, ), and suboptimally controlled asthmatic (red triangles, ) neutrophils stimulated with (a) bacterial compounds: lipopolysaccharide (LPS), f-Met-Leu-Phe (fMLF), and DMSO (vehicle control), (b) viral surrogates: imiquimod, R848, and polyinosinic:polycytidylic acid (poly I:C), and (c) RV16 after 1 hour. Raw data is presented as a scatter plot with median. , , , and compared to unstimulated control. between indicated disease groups.

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