Intracellular Cleavage of the Cx43 C-Terminal Domain by Matrix-Metalloproteases: A Novel Contributor to Inflammation?

Table 2

Results of cleavage site prediction based on PROSPER  in silico analysis.

Matrix-metalloprotease	Position	Segment	Probability score
MMP-2	357^#	QPLA −/− IVDQ	1.06
MMP-9	357^#	QPLA −/− IVDQ	1.21
	285^#	SPPG −/− YKLV	1.10
	248	DPYH −/− ATTG	1.08
	231	LFYV −/− FFKG	1.08
	359	LAIV −/− DQRP	1.03
	287	PGYK −/− LVTG	1.01
	334	HAQP −/− FDFP	0.98
	277	PTAP −/− LSPM	0.97
	379	RPDD −/− LEI	0.96

https://prosper.erc.monash.edu.au; ^#also identified by SitePrediction.