γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation

Figure 2

γ-Secretase inhibitor (GSI) reduced OVA-induced airway inflammation. (a) BALB/C mice were sensitized i.p. with OVA and challenged with OVA in the presence and absence of GSI. Mice were sacrificed within 24 hr after last challenge. Lung tissues were stained with haematoxylin and eosin and subjected to light microscope (×200) examination. (b) Semiquantitative pathology scores among sham, OVA, and OVA + GSI groups. Data expressed as Mean ± SEM. mice per group. compared with the sham group; compared with the vehicle group.

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