Marine Diterpenoids as Potential Anti-Inflammatory Agents

Table 3

Anti-inflammatory effect of cembrane diterpenoids.

	Families name	Biological source	COX-2	iNOS	NFκB
	Crassarines	Sinularia crassa		H [118]
	Grandilobatins	S. grandilobata		D [110]
	Querciformolides	S. querciformis	C [111]	C [111]; E [115]
	Sinumaximols	S. maxima			A-C, G, I [126]
	Sarcocrassocolides	Sarcophyton crassocaule	I [117]; Q [120]	A-D [116]; F-L [117]; M-O [119]; P-R [120]
	Crassocolides	S. crassocaule	A, E [120]	A-B, D-E [120]
	Crassumolides	Lobophytum crassum	A, C [112]	A-C, F [112]
	Crassumols	L. crassum			E [124]
	Lobocrasols	L. crassum			A-C [125]
	Durumolides	L. durum	C [113]; F [114]	A-E [113]; F-L [114]
	Laevigatols	L. laevigatum			A-B [123]
	Columnariols	Nephthea columnaris (cultured coral)	A-B [121]	A-B [121]

Data refer to compounds with percentage of inhibition > 50% for COX-2 and iNOS and IC₅₀ values < 50 μM in NFκB.