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Mediators of Inflammation
Volume 2015, Article ID 265056, 11 pages
http://dx.doi.org/10.1155/2015/265056
Research Article

Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

1Department of Anesthesiology, Xuzhou Cancer Hospital, Affiliated Xuzhou Hospital, Jiangsu University, Xuzhou 221005, China
2Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China
3Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou 221002, China
4Department of Anesthesiology, Xuzhou Children’s Hospital, Xuzhou 221006, China
5Department of Anesthesiology, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221006, China
6Department of Oncology, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221006, China
7Department of Pain, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221006, China
8Department of Anesthesiology, Xuzhou Maternity and Child Health Hospital, Xuzhou 221009, China

Received 23 July 2015; Accepted 5 November 2015

Academic Editor: Robert LaMotte

Copyright © 2015 Shanshan Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite this Article

Shanshan Zhu, Chenchen Wang, Yuan Han, Chao Song, Xueming Hu, and Yannan Liu, “Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation,” Mediators of Inflammation, vol. 2015, Article ID 265056, 11 pages, 2015. https://doi.org/10.1155/2015/265056.