Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

Figure 5

Blocking sigma-1 receptor activation suppressed BCP-induced upregulation of p-NR1 and p-ERK1/2 in the spinal cord. (a) Western blot analysis indicated a significant increase of p-NR1 and p-ERK expression in the spinal cord of BCP rats on day 7. Repetitive treatment with BD1047 significantly decreased these molecules in BCP rats compared with NS-treated BCP group. (b) Quantification of p-NR1 and p-ERK expression level in the spinal cord (). Results are given as means ± SEM. , versus sham + NS group; , versus BCP + NS group.

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