Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

Figure 7

Iba-1, p38 activation. and proinflammatory cytokine expression were reduced by intrathecal administration of BD1047. (a) Western blot analysis indicated that Iba-1, p-p38, and TNF-α expression were higher in the spinal cord of BCP rats on day 7. Intrathecal BD1047 significantly reduced the expression of these molecules in BCP rats compared with NS-treated BCP group. (b) Quantification of Iba-1, p-p38, and TNF-α expression level in the spinal cord (). Results are given as means ± SEM. , versus sham + NS group; , versus BCP + NS group.

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