Mediators of Inflammation / 2015 / Article / Fig 2

Review Article

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation

Figure 2

Cadherins can regulate PTK activity. The proposed mechanisms include the direct modulation of kinases and phosphatases as well as interactions with receptor tyrosine kinases. Cadherin-mediated PTK activity has been shown to be involved in mechanosensory transduction, contact inhibition of cell proliferation, and strength of cell adhesion.