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Mediators of Inflammation
Volume 2015 (2015), Article ID 313140, 9 pages
Research Article

Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse

1Departamento de Inmunología, Laboratorio de Inmunología Clínica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11340 Mexico, DF, Mexico
2Departamento de Anatomía Patológica, Laboratorio de Patología Molecular, Instituto Nacional de Pediatría, 04530 Mexico, DF, Mexico

Received 27 September 2014; Accepted 5 January 2015

Academic Editor: Madhav Bhatia

Copyright © 2015 Berenice Sánchez-González et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


BALB/c strain mice are unique in that they develop murine plasmacytoma (MPC) as a consequence of the inflammation induced by pristane oil injection in the peritoneal cavity. In this work the Treg, Th17, B1, B2, and NHC lymphocyte populations from the peritoneal environment of BALB/c, the susceptible strain, and C57BL/6 mice, which do not develop MPC after oil treatment, were studied. Both oil-treated strains showed decreased levels of Th17 lymphocytes, no significant variation in Treg lymphocytes, and a drastic decrease of all B lymphocyte populations. However, only oil-induced BALB/c showed increased levels of natural helper cells (NHC) which could be important in the myeloma induction.