Review Article

Is Pulp Inflammation a Prerequisite for Pulp Healing and Regeneration?

Figure 7

Illustration of nemosis process. Direct cell-cell interactions between diploid fibroblasts induce cell activation leading to programmed cell death. Nemosis of fibroblast generates large amounts of mediators of inflammation, such as prostaglandins, as well as growth factors. Factors secreted by nemotic fibroblasts also break down the extracellular matrix. Such factors include several MMPs and plasminogen activation.