Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension

Table 4

Top 25 diseases associated with IPH in Ingenuity iReport.

Number	Disease	DEGs	value	Genes
1	Immunodeficiency	6		CD28, CXCR4, RASGRP1, ADA, CD79A, IGLL1/IGLL5
2	Leprosy	5		CD28, SLAMF1, TGFB1, CD79A, IGLL1/IGLL5
3	Transcytosis of HIV-1	2		CXCR4, CD79A
4	Genital tumor	15	0.000101439	CXCR4, CDK7, FOLH1, STAP1, MKI67, GPX3, ABCA8, TGFB1, ABCC1, SERPINA5, CD44, EDNRA, PTGER2, TNFRSF11B, PEG3
5	Agammaglobulinemia	2	0.000135709	CD79A, IGLL1/IGLL5
6	Metastasis of tumor	5	0.000161747	CD28, TGFB1, CXCR4, CD44, PTGER2
7	Digestive organ tumor	20	0.000177474	ERAP2, HIST1H4A, CXCR4, CDK7, PTTG1, FOLH1, TPD52L1, MELK, MKI67, IGLL1/IGLL5, GPX3, TGFB1, OIT3, ABCC1, C7, E2F5, CD44, MMP12, PEG3, TNFRSF11B
8	Colorectal cancer	14	0.000211188	ERAP2, HIST1H4A, CXCR4, PTTG1, CDK7, FOLH1, TPD52L1, MELK, MKI67, GPX3, TGFB1, CD44, TNFRSF11B, PEG3
9	Tuberculoid leprosy	3	0.000255384	CD28, SLAMF1, CD79A
10	Metastasis	10	0.000432136	CD28, ERAP2, TGFB1, CXCR4, PTTG1, CD44, MLLT4, PTGER2, PEG3, TNFRSF11B
11	Granulocyte colony stimulating factor-induced psoriasiform dermatitis	2	0.000470563	TGFB1, MKI67
12	Rectum cancer	3	0.0005718	GPX3, CD44, MKI67
13	Vascular disease	11	0.00075445	NPR3, SERPINA5, MARC1, TGFB1, EDNRA, PTGER2, CD44, MMP12, CD28, MKI67, CXCR4
14	Infection by bacteria	8	0.00090366	CD28, SLAMF1, TGFB1, SERPINA5, CD44, MMP12, CD79A, IGLL1/IGLL5
15	Replication of HIV-1	4	0.00121203	CD28, TGFB1, CXCR4, PLA2G10
16	Pulmonary hypertension	3	0.001305595	NPR3, CXCR4, EDNRA
17	Prostatic tumor	9	0.001615688	GPX3, TGFB1, CXCR4, FOLH1, CD44, EDNRA, STAP1, MKI67, TNFRSF11B
18	Uterine serous papillary cancer	6	0.001802487	ABCA8, P2RY14, PTTG1, C7, EDNRA, PEG3
19	Fibrosis of lung	5	0.001814056	TGFB1, PLA2G10, ADA, EDNRA, MMP12
20	Cancer	33	0.001947463	ERAP2, HIST2H2BE, PTTG1, FOLH1, TPD52L1, MLLT4, MELK, MKI67, CD79A, IGLL1/IGLL5, GPX3, CD28, SARNP, TGFB1, ABCC1, C7, E2F5, ADA, MMP12, TNFRSF11B, PEG3, HIST1H4A, CXCR4, CDK7, STAP1, ABCA8, P2RY14, RASGRP1, OIT3, SERPINA5, CD44, EDNRA, PTGER2
21	Endometrial carcinoma	8	0.002077475	GPX3, ABCA8, P2RY14, TGFB1, PTTG1, C7, EDNRA, PEG3
22	Neuroblastoma	3	0.002212756	CXCR4, ABCC1, CD44
23	Edema of tissue	2	0.002294982	TGFB1, SPRED2
24	Carcinoma	28	0.002351502	ERAP2, HIST2H2BE, PTTG1, FOLH1, TPD52L1, MELK, MKI67, IGLL1/IGLL5, GPX3, TGFB1, ABCC1, C7, E2F5, MMP12, TNFRSF11B, PEG3, HIST1H4A, CXCR4, CDK7, STAP1, ABCA8, P2RY14, RASGRP1, OIT3, SERPINA5, CD44, EDNRA, PTGER2
25	Polyuria	3	0.002583567	NPR3, PTTG1, ABCC1

Underlined genes indicate increases in expression. Not underlined genes indicate decreases in expression.
DEGs: differentially expressed genes.