Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants
Table 1
Clinical characteristics at baseline (before transplantation) and at 3 months and 12 months after transplantation.
Characteristics
Baseline ()
3 months after transplantation ()
12 months after transplantation ()
Age at transplantation (years)
46.6 ± 12
45.1 ± 11.9
48.3 ± 15.8
Female ()
6
6
4
BMI (kg/m2)
25.1 ± 3.26
24.7 ± 3.3
28.9 ± 4.1
Systolic BP (mmHg)
149.5 ± 13.6
128.3 ± 14.7
143.9 ± 18.1
Diastolic BP (mmHg)
86 ± 7.8
73.3 ± 11.8
81.5 ± 10.8
Blood urea nitrogen, BUN (mg/dL)
39.8 ± 20.8
22.9 ± 5.1
24.3 ± 8
Triglycerides (mg/dL)
121.30 [62.27–386.37]
135.60 [73.90–246.34]
103.40 [84.44–242.00]
Total cholesterol (mg/dL)
152.4 ± 36.5
187.3 ± 26.4
198.3 ± 81.7
Glycerol (mg/dL)
28.5 ± 23.1
29.4 ± 11.6
39.1 ± 33.8
Serum apoA-I (mg/dL)
76.76 [9.68–92.61]
71.99 [48.43–90.33]
79.19 [45.04–89.19]
Serum apoB (mg/dL)
129.13 [74.29–186.95]
115.84 [59.21–254.67]
158.20 [61.96–190.96]
Non-HDL cholesterol (LDL + VLDL, mg/dL)
107.1 ± 22.2
97.6 ± 27.3
118.2 ± 18.6
HDL cholesterol (mg/dL)
52.9 ± 16.7
65.8 ± 30.4
52.6 ± 17.7
TBARS (LDL + VLDL) (MDA nmoles/mL)
7.7 ± 5.7
7.5 ± 6.3
6.9 ± 3.0
Myeloperoxidase (mU/mL)
109.7 ± 27.0
110.4 ± 50.1
73.9 ± 53.0
Serum creatinine (mg/dL)
7.9 ± 2.5
1.2 ± 0.2
1.2 ± 0.3
eGFR (mL/min) (MDRD)
N/A
73.6 ± 14.5
74.9 ± 15.9
hs-CRP (mg/L) (median)
<4
<4
<4
Hemoglobin (g/dL)
11.3 ± 2
12.5 ± 1.4
13.1 ± 1.4
Albumin (g/dL)
4.1 ± 0.4
4.3 ± 0.2
4.1 ± 0.1
Data are presented as means ± SD or medians [interquartile ranges]. Values from baseline (before transplantation) and 3 months and 12 months (after transplantation) were compared using nonparametric test (data were significant at , , and ). Fourteen patients had creatinine 1.5 at 3 or 12 months after transplantation; two of the 14 patients were not included at 3 months because creatinine was >1.5. The graft function of these two patients improved to creatinine of 1.5, so, together with 6 patients included at 3 months, they make up 8 patients at 12 months. 50% of patients had values <4 (lower limit of detection for assay = 4 mg/L).
