Proinflammatory Cytokines and Potassium Channels in the Kidney

Figure 3

Illustration of the acute effect of TNF-α on the 70 pS K⁺ channel in the TAL. TNF-α stimulates PTP activity, which causes tyrosine dephosphorylation of the 70 pS K⁺ channel and activates it. TNFR: TNF receptor.