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Mediators of Inflammation
Volume 2015, Article ID 405629, 9 pages
Research Article

ISU201 Enhances the Resolution of Airway Inflammation in a Mouse Model of an Acute Exacerbation of Asthma

1Inflammation and Infection Research, School of Medical Sciences, UNSW Australia, Sydney, NSW 2052, Australia
2Isu Abxis Co., Ltd., 696-1 Sampyeong-dong, Bundang-ku, Seongnam 463-400, Republic of Korea

Received 4 December 2014; Revised 7 January 2015; Accepted 12 January 2015

Academic Editor: Sandra Helena Penha Oliveira

Copyright © 2015 Yuka Hiroshima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Treatment with ISU201 after the induction of an acute exacerbation had no effect on the expression of mRNA for the chemokines Ccl2, Ccl3, Ccl11 and Cxcl1 or for Il13, and reduced mRNA for Ccl4 only at 24 hours. In contrast, treatment with dexamethasone reduced expression of these mRNA species at every time point examined.

  1. Supplementary Figure