A Novel Minimal Invasive Mouse Model of Extracorporeal Circulation

Figure 2

Systemic inflammatory response induced by ECC. Mice in the ECC group were perfused for 30 min in the ECC circuit shown in Figure 1 and then observed for 60 min. Mice in the Sham group were observed without ECC for 90 min. Mice in the Naïve group were anesthetized for 90 min, and samples were harvested at once. Systemic inflammatory response was assessed by measuring plasma levels of (a) NE, (b) IL-6, and (c) TNF-α at 60 min after the end of ECC. Each treatment group contained 20 animals. ECC, extracorporeal circulation; IL-6, interleukin-6; NE, neutrophil elastase; TNF-α, tumor necrosis factor-α. and versus Sham. ^# and ^## versus ECC.

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