Allicin Alleviates Inflammation of Trinitrobenzenesulfonic Acid-Induced Rats and Suppresses P38 and JNK Pathways in Caco-2 Cells

Figure 1

(a) Morphology of the colon in each group. TNBS induced a marked colon lesion, and, 14 days later, different treatments diminished the congestions and intumescences in varying degrees. Allicin combined with sulfasalazine or mesalazine reversed the damage of the colon. (b) The weight curve of rats. The day after the edema, rats lost weight significantly by TNBS inducing, even treated by drugs. At day 14, weights of control, allicin, mesalazine, and mesalazine + allicin groups had no significant difference. Each point represents mean ± SD of each group at certain days ( in control and mesalazine + allicin groups, in sulfasalazine group, in sulfasalazine + allicin group, in allicin prevention and allicin groups, and in TNBS and mesalazine groups). versus control group; ^# versus TNBS group.

(a)

(b)