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Mediators of Inflammation
Volume 2015 (2015), Article ID 435783, 7 pages
http://dx.doi.org/10.1155/2015/435783
Review Article

Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?

1Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, Brazil
2Laboratório de Medicina Intensiva, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, RJ, Brazil
3Instituto D’Or de Pesquisa e Ensino, 22281-100 Rio de Janeiro, RJ, Brazil

Received 19 September 2014; Revised 24 January 2015; Accepted 26 January 2015

Academic Editor: Bernardo S. Franklin

Copyright © 2015 Eugenio D. Hottz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Platelets are crucial effector cells in hemostasis. In addition, platelets are increasingly recognized as major inflammatory cells with key roles in innate and adaptive immune responses. Activated platelets have key thromboinflammatory activities linking coagulation to inflammatory response in a variety of coagulation disorders and vasculopathies. Recently identified inflammatory activities of platelets include the synthesis of IL-1β from spliced pre-RNA, as well as the presence and assembly of inflammasome which intermediate IL-1β secretion. Here we review the mechanisms by which platelets activate translation machinery and inflammasome assembly to synthesize and release IL-1β. The contributions of these processes to protective and pathogenic responses during infectious and inflammatory diseases are discussed.