Mediators of Inflammation

Research Article

Gene Expression Profiling of IL-17A-Treated Synovial Fibroblasts from the Human Temporomandibular Joint

Table 2

IL-17-responsive genes in synovial fibroblasts form TMJ.
Gene symbol GenBank IDFold Gene name
Upregulated    
Molecular function    
 Chemokine activity    
  CCL8 NM_00562351.25 Chemokine (C-C motif) ligand 8
  CXCL1 NM_00151149.84 Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
  CXCL2 NM_00208938.77 Chemokine (C-X-C motif) ligand 2
  CXCL3 NM_00209035.88 Chemokine (C-X-C motif) ligand 3
  CXCL8 NM_00058424.65 Chemokine (C-X-C motif) ligand 8
  CCL20 NM_00459115.72 Chemokine (C-C motif) ligand 20
  CXCL6 NM_00299313.00 Chemokine (C-X-C motif) ligand 6
  CCL7 NM_00627311.10 Chemokine (C-C motif) ligand 7
  CCL2 NM_0029822.95 Chemokine (C-C motif) ligand 2
 Cytokine activity    
  AREG NM_0016573.32 Amphiregulin
  NAMPT AK0233413.03 Nicotinamide phosphoribosyltransferase
  BMP2 NM_0012002.96 Bone morphogenetic protein 2
  NDP NM_0002662.83 Norrie disease (pseudoglioma)
 Cytokine receptor binding    
  CSF2 NM_00075817.62 Colony stimulating factor 2 (granulocyte-macrophage)
  IL-6 NM_00060017.19 Interleukin-6
  CSF3 NM_00075912.62 Colony stimulating factor 3 (granulocyte)
  LIF NM_0023095.70 Leukemia inhibitory factor
  IL1RN NM_1738432.72 Interleukin-1 receptor antagonist
  IL1B NM_0005762.62 Interleukin-1, beta
 Growth factor activity    
  NTF4 NM_0061797.22 Neurotrophin 4
  NRG3 NM_0010108485.55 Neuregulin 3
 Growth factor receptor binding    
  EREG NM_0014323.18 Epiregulin
  FRS3 NM_0066532.86 Fibroblast growth factor receptor substrate 3
  FGF5 NM_0331432.67 Fibroblast growth factor 5
 G-protein coupled receptor binding    
  ADORA2A NM_0006754.16 Adenosine A2a receptor
  RTP1 NM_1537083.37 Receptor (chemosensory) transporter protein 1
  PDE4D NM_0011658992.17 Phosphodiesterase 4D, cAMP-specific
 Receptor binding    
  EPHA7 NM_0044404.88 EPH receptor A7
  ICAM4 NM_0223772.77 Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
  STC1 NM_0031552.73 Stanniocalcin 1
  CD74 NM_0010251582.58 CD74 molecule, major histocompatibility complex, class II invariant chain
  HILPDA NM_0133322.30 Hypoxia inducible lipid droplet-associated
  EFNB2 NM_0040932.12 Ephrin-B2
  DOK3 NM_0248722.07 Docking protein 3
  PTPN2 NM_0028282.05 Protein tyrosine phosphatase, nonreceptor type 2
Downregulated    
Molecular function    
 Signaling receptor activity    
  HNF4A NM_001030004−5.42 Hepatocyte nuclear factor 4, alpha
  CASS4 NM_020356−3.21 Cas scaffolding protein family member 4
  NR0B1 NM_000475−2.51 Nuclear receptor subfamily 0, group B, member 1
  NR1I3 NM_001077474−2.05 Nuclear receptor subfamily 1, group I, member 3
 Transmembrane signaling receptor activity    
  TACR1 NM_015727−97.28 Tachykinin receptor 1
  CD3E NM_000733−66.90 CD3e molecule, epsilon (CD3-TCR complex)
  OR12D2 NM_013936−66.54 Olfactory receptor, family 12, subfamily D, member 2
  OR13J1 NM_001004487−64.29 Olfactory receptor, family 13, subfamily J, member 1
  LILRB5 NM_006840−57.98 Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
  OR52N2 NM_001005174−54.24 Olfactory receptor, family 52, subfamily N, member 2
  TAS2R40 NM_176882−52.34 Taste receptor, type 2, member 40
  TAS2R4 NM_016944−12.98 Taste receptor, type 2, member 4
  CHRNA7 NM_001190455−9.25 Cholinergic receptor, nicotinic, alpha 7 (neuronal)
  TULP1 NM_003322−7.60 Tubby-like protein 1