Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels

Figure 4

Histological features of vehicle- and benidipine-treated CRF rat kidneys and the expression of proinflammatory cytokines. (a) Hematoxylin and eosin staining (H&E) in vehicle-treated and benidipine-treated CRF rat kidneys. Low-power views of the cortex. Magnification, ×20. (b) Immunohistochemistry using antibody for Ki-67 (brown) in vehicle- and benidipine-treated CRF rat kidneys. High-power views of the cortical interstitium. Magnification, ×60. (c) The abundance of IL-2 mRNA (left) and interferon-γ (IFN-γ) (right) in the renal cortex of vehicle-treated and benidipine-treated CRF rat kidneys. versus vehicle-treated CRF rats. Values are means ± SEM (). Differences were analyzed by ANOVA followed by Dunnett’s or Student’s -test. Modified from [34].

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