The Inflammatory Actions of Coagulant and Fibrinolytic Proteases in Disease

Figure 1

The proinflammatory and proremodelling actions of coagulant and fibrinolytic proteases. In tissue injury and disease, the proteases FXa, FVIIa, thrombin, plasmin, uPA, and tPA not only participate in extravascular coagulation (green pathway) or fibrinolysis (red pathway), but also mediate inflammation and tissue remodelling. The cell-mediated actions of the individual proteases can overlap (i.e., PAR-1 activation by FXa, thrombin, and plasmin) and/or be interconnected (i.e., the generation of FDPs by both coagulation and fibrinolytic pathways).