MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction

Figure 1

miR-208a agomir and antagomir transfection significantly upregulated or downregulated miR-208a, respectively (, ). (a) miR-208a antagomir transfection significantly downregulated miR-208a in cultured neonatal cardiomyocytes 48 hours after transfection ( samples per group). (b) Agomir transfection into neonatal cardiomyocytes significantly upregulated miR-208a ( samples per group). (c) miR-208a antagomir significantly downregulated miR-208a at 28 days after MI ( per group).

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