Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction
αMHC.IGF-1Ea improves cardiac function and reduces dilation as early as 7 days after myocardial infarction. (a) Levels of IGF-1Ea in the ischemic and in the remote area of WT hearts at 1, 3, 5, 7, and 28 days following MI. (b) Left ventricular ejection fraction (LVEF) and (c) left ventricular end systolic volume (LVESV) after MI. Solid lines represent WT mice. Dashed lines represent αMHC.IGF-1Ea mice. Levels of (d) actin-alpha 1 skeletal muscle (ACTA 1) and (e) atrial natriuretic peptide (ANP) mRNA expression 28 days after MI. Results are expressed as mean fold induction ± SEM over the values of uninjured hearts. –6 per group. Two-tailed Student’s t-test was performed to compare WT versus αMHC.IGF-1Ea at selected time points after MI. , .