Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction
Cytokine dynamics in the infarcted αMHC.IGF-1Ea hearts. (a) Interleukin- (IL-) 1β, (b) MCP-1, (c) IL-10, (d) CCL5 at several time points after permanent ligation. Solid lines represent WT mice. Dashed lines represent αMHC.IGF-1Ea mice. Results are expressed as mean fold induction ± SEM over the values of uninjured hearts. per group. Two-tailed Student’s t-test was performed to compare WT versus αMHC.IGF-1Ea at selected time points after MI. , .