Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans
Table 1
Anthropometric, biochemical, and immunological characteristics of the study subjects.
Control subjects
MO
MO+OSA
Control versus MO
Control versus MO+OSA
MO versus MO+OSA
Male proportion (%)
8 (80)
2 (15)
4 (13)
0.0018
0.0002
>0.9
Age (years)
43.4 ± 11.5
33.5 ± 10.9
37.2 ± 11.4
0.09
0.3
>0.9
Body mass index (kg/m2)
23.6 ± 2.1
45.4 ± 8.2
45.2 ± 8.4
<0.0001
<0.0001
>0.9
Abdominal circumference (cm)
84.3 ± 6.7
129.9 ± 21.9
124.2 ± 16.4
<0.0001
<0.0001
>0.9
Fasting blood glucose (mmol/L)
5.0 ± 0.5
6.87 ± 0.27
6.7 ± 0.57
<0.0001
<0.0001
0.8
Fasting blood insulin (mU/L)
13.5 ± 1.8
17.4 ± 5.1
22.9 ± 5.6
0.16
<0.0001
0.0052
HOMA-IR
3 ± 0.4
5.3 ± 1.6
6.9 ± 1.8
0.0042
<0.0001
0.01
Total cholesterol (mg/dL)
192.3 ± 36.1
198.8 ± 29
201.6 ± 46.1
0.9
0.8
0.9
Total triglyceride (mg/dL)
121.8 ± 37.4
215.8 ± 59.1
227.3 ± 62.8
0.0008
<0.0001
0.8
IL-12 (pg/mL)
217.4 ± 43
394 ± 64.7
405.3 ± 57.4
0.0002
<0.0001
0.9
TNF-α (pg/mL)
270.2 ± 31.7
306.9 ± 38.9
337.9 ± 67.8
0.12
0.0031
0.8
IL-10 (pg/mL)
113.2 ± 12.10
97.2 ± 10.9
74.40 ± 17.0
0.36
<0.0001
0.0012
HOMA-IR, homeostatic model assessment-insulin resistance; AHI, apnea-hypopnea index; TNF-α, tumor necrosis factor alpha; IL, interleukin; NS, nonsignificant differences. Data are presented as mean ± standard deviation. Differences were considered significant when .
