The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors

Figure 6

The transfer of splenic lymphocytes from a Pfp donor to a Pfp recipient fails to restore responses to dexamethasone. Data are Mean + SEM of total nucleated cell (a), EPO+ cell (b), and neutrophil (c) counts in freshly harvested bone-marrow of Pfp mice which had received 10⁷ total nylon-wool purified Pfp lymphocytes, i.v., 48 h before dexamethasone (5 mg/kg) injection. For both saline-injected and dexamethasone injected mice, .

(a)

(b)

(c)