Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs

<div>TNF-<i>α</i> or VEGF-mediated NF<i>κ</i>B activation promotes inflammation and opening up of EC junctions leading to increased vascular permeability. Increased VCAM-1 is associated with altered EC function and recruitment of immune cells. We propose (A) Inhibition of SK1. (B) Increased miRNA levels will reduce TNF-<i>α</i> or VEGF-mediated NF<i>κ</i>B activation and reduce VCAM-1 expression leading to maintenance or improvement of vascular integrity.</div>

Mediators of Inflammation

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Figure 1

Figure 1: Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs 